GPCR Binding-Functional Assay Pairings
For your convenience, CDAS provides the following table which lists GPCR binding assays that have their corresponding functional assays. Please refer to this table frequently as we are updating our availability of functional assays on a regular basis.
LF = Label Free
Dev't = In Development
|
Binding Assay |
Binding |
Agonist |
Antagonist |
Platform |
|
Adenosine, A2A, (h) |
Dev't |
Dev't |
|
|
|
Adrenergic, Alpha 1A |
LF |
|||
|
Adenosine, Transporter AOT (h) |
RL Transport |
|||
|
Adrenergic, Alpha 2A (h) |
LF |
|||
|
Adrenergic, Alpha 2B (h) |
LF |
|||
|
Adrenergic, Alpha 2C (h) |
cAMP |
|||
|
Adrenergic, Beta 1 (h) |
LF |
|||
|
Adrenergic, Beta 2 |
cAMP |
|||
|
Anandamide, Transport AMT (h) |
|
|
RL Transport |
|
|
Bradykinin, B1 |
|
Ca2+ Flux |
||
|
Bradykinin, B2 |
|
Ca2+ Flux |
||
|
Cannabinoid, CB1 (h) |
LF |
|||
|
Cannabinoid, CB2 (h) |
Dev't |
Dev't |
|
|
|
Chemokine, CCR2 (h) |
|
Ca2+ Flux |
||
|
Chemokine, CXCR2 (h) |
|
LF |
||
|
Complement, Anaphylatoxin C3a (h) |
|
Dev't |
Dev't |
|
|
Choline, Transport ChOT |
|
|
RL Transport |
|
|
Complement, Anaphylatoxin C5a (h) |
|
LF |
||
|
Corticotropin Releasing Factor, CRF1 (h) |
cAMP |
|||
|
Dopamine, D1 (h) |
cAMP |
|||
|
Dopamine, DA2L (h) |
LF |
|||
|
Dopamine, D4.4 (h) |
Dev't |
Dev't |
GTP |
|
|
Dopamine, Transporter, DAT |
|
RL Transport |
||
|
GABA, Transport |
|
|
RL Transport |
|
|
Galanin 1 (h) |
Dev't |
Dev't |
|
|
|
Glutamate, GLUT |
|
|
RL Transport |
|
|
Histamine, H1 (h) |
LF |
|||
|
Histamine, H2 |
cAMP |
|||
|
Leukotriene, LTB4 (BLT1) (h) |
Ca2+ flux |
|||
|
Leukotriene, LTB4 (CysLT1) (h) |
|
Ca2+ flux |
||
|
Lysophospholipid, LPA2 (h) |
|
Ca2+ flux |
||
|
Lysophospholipid, S1P3 (h) |
|
Ca2+ flux |
||
|
Muscarinic, M1 (h) |
Ca2+ flux |
|||
|
Muscarinic, M3 (h) |
|
Ca2+ flux |
||
|
Neurokinin, NK2 (NKA) (h) |
Dev't |
LF |
||
|
Neurokinin, NK2 (h) |
Ca2+ flux |
|||
|
Nicotinic, a-BnTx Insensitive Neuronal (h) |
Ca2+ flux |
|||
|
Norepinephrine, Transporter NET |
|
RL Transport |
||
|
Norepinephrine, Transporter NET (h) |
|
RL Transport |
||
|
Opioid, Mu (h) |
GTPgS |
|||
|
Opioid, Nociceptin ORL1 (h) |
LF |
|||
|
PAF (h) |
|
Ca2+ flux |
||
|
PGE2 |
|
cAMP |
||
|
Potassium, hERG (I[Kr]) (h) |
|
Rb flux |
||
|
Purinergic, P2Y (h) |
Ca2+ flux |
|||
|
Serotonin, 5HT1A (h) |
LF |
|||
|
Serotonin, 5HT2B (h) |
Ca2+ Flux |
|||
|
Serotonin, 5HT2C (h) |
Ca2+ Flux |
|||
|
Serotonin, 5HT3 |
Membrane Potential |
|||
|
Serotonin, Transporter SERT (h) |
|
RL Transport |
||
|
Vasopressin, V2 (h) |
|
LF |
||
|
Vesicular, VMAT2 Transporter |
|
|
RL Transport |
|
|
Vesicular, VMAT1 |
|
RL Transport |