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IVIS® Kinetic


The IVIS Kinetic from Caliper Life Sciences provides a real time, fast imaging system enabling acquisition of biologically relevant events within milliseconds. The IVIS Kinetic can perform both quantitative luminescence and fluorescence as a standard high signal to noise imager and as a high speed imager. The system includes a highly sensitive EMCCD camera for signal enhancement and the ability to reduce exposure times enabling fast kinetics. From the leading optical imaging platform for in vivo analysis, IVIS systems are supported by a range of practical accessories developed through experience in research laboratories worldwide. The IVIS Kinetic offers a light-tight injection port which supporting a syringe injector system enabling real time compound and/or substrate administration. A removable pull-out tray is available to facilitate pre-imaging animal procedures.

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or contact David Panzarella at +1-845-735-1921 or David.Panzarella@perkinelmer.com.




Applications

• Oncology Research (PDF)
• Infectious Disease
• Inflammation
• Metabolic Diseases
• Neurology
• Gene Therapy
• Stem cell Biology
• Cardiovascular Disease
• Immunology & Transplantation Biology
• Toxicology (PDF)
• Drug Metabolism Studies

Features

The IVIS Kinetic has all the features you would expect from an IVIS Lumina and the EM Gain feature which significantly enhances your signal and reduce exposure times required to detect real-time luminescent or fluorescent signals. EMCCD cameras are the optimal choice in performing a wide range of fast, real time data acquisitions due its fast frame transfer chip design and overall longterm camera stability in comparison to other fast imaging technologies. EMCCD’s  allows the user to perform long exposure (no EM gain) imaging procedures and fast kinetic apploications with the same camera while achieving higher quantum effeciences and low detector noise.

Some of the features include:
• High-sensitivity in vivo and in vitro imaging of fluorescence and bioluminescence
• Adjustable field of view from 0.5 - 12.5 cm2 
• Camera CCD 
   - The IVIS Kinetic EMCCD is 13.3 x 13.3 mm square, with 1024 x 1024 pixels 13 micron in width
   - Back-thinned, back-illuminated grade 1 CCD provides high quantum efficiency
   - Frame transfer technology yields rapid image readout speeds 
   - 14 and 16 bit digitizer delivers broad dynamic range
   - The CCD is thermoelectrically (Peltier) cooled to -80 ºC ensuring low dark current and low noise
• 10 position excitation filter wheels
• 4 filter wheel choices for a broad range of fluorescence applications
• Heated stage to maintain optimum body temperature
• Motor controlled stage, filter wheel, lens position, and f-stop
• NIST traceable absolute calibrations
• Gas anesthesia inlet and outlet ports

Demos

Our product can be demonstrated at our facility in Hopkinton, Massachussetts or other Caliper Life Sciences offices worldwide.  Please contact your local Caliper Representative to arrange a demo.

Specifications

Power Requirements
6A at 120V

Dimensions
Space Requirement: 48 x 71 x 104 cm (W x D x H)

Temperature Range
Ambient to 80°

Operating System Software
1 acquisition copy and 4 analysis copies of Living Image software 3.1.x and higher

Camera Sensor
Back-thinned, back-illuminated, cooled Grade 1 CCD, frame transfer

CCD
Size 13 x 13 μm
Operating Temperature -80 ºC (Optional chiller to achieve -90 ºC)

Imaging Pixels
1024 x 1024

Quantum Efficiency
>85% at 500 – 700 nm, >30% at 400 – 900 nm

Pixel Size
13.0 microns

Minimum Detectable Radiance
100 photons/s/sr/cm2

Field of View (FOV)
Minimum FOV 5 x 5 cm
Maximum FOV 12.5 x 12.5 cm (optional 24 x 24 cm)

Minimum Image Pixel Resolution
50 microns

Read Noise
6-47 (Gain and Read-out Speed Dependant)

Dark Current (Typical)
<3 x 10-4 e-/pixel/s

Fluorescence Filters
Excitation 10 high resolution filters standard on all instruments
Emission 5 sets available to choose from: One standard resolution set of 4 filters and 4 sets of 7 high resolution filters

Computer
2.8 GHz, 1 GB RAM, RW CD/DVD, 80 GB HD, 20” flat screen monitor (minimum requirements)

Lens
f/.95 – f/16, 50 mm

Stage Temperature
20 – 40°C

Imaging Chamber Dimensions
43 x 38 x 43 cm (W x D x H)