Caliper Owners Group (COG)

COG is more than a collection of individuals using technologies from Caliper

It is an organization of innovative scientists deploying leading edge technologies to advance research and improve the human condition. COG provides a forum to network with colleagues, share best practices and participate in thought-leadership discussions.

The goals of COG and the annual meeting are to enable users to share best practices for instrument use and technology adoption; share feedback on future directions and key improvements requested; provide early access to new releases from Caliper; and create a networking event for users.

COG 2011 Presentations

Keynote Presentations
	The Practice of Medicine in the 21^st Century (1.5 MB) Dennis Ausiello, MD Physician-in-Chief, Department of Medicine, Massachusetts General Hospital Jackson Professor of Clinical Medicine, Harvard Medical School Chief Scientific Officer, Partners Healthcare
	Optical Imaging, From Bench to Bedside Go van Dam, MD/Ph.D. Surgeon, University Medical Center Groningen - The Netherlands
	African Genomics: Charting Human Diversity Stephan Schuster, Ph.D. Professor of Biochemistry and Molecular Biology, Pennsylvania State University
	Disruptive Technologies, Collaborations and Culture Enabling Personalized Medicine Kevin Hrusovsky President & CEO, Caliper Life Sciences

In Vivo Imaging
	The "Ions" of In Vivo Optical Imaging (2.5 MB) Thomas Krucker, Novartis Institute for Biomedical Research
	Cerenkov Luminescent Imaging Following Drug Treatment (601 KB) Robbie Robertson, Millennium - The Takeda Oncology Company
	Targeted Imaging: The Trace for Targets (918 KB) Marleen van Oosten, UMCG
	Intraoperative Fluorscence Imaging in Oncology: Clinical Results (3.0 MB) Lucia M.A. Crane, University Medical Center Groningen
	Cross-Talking Between Respiratory R&D and BLI (1.9 MB) Fabio Stellari, Chiesi

Tissue Imaging
	Examples of Tissue Brightfield Quantitative Image Analysis using the Vectra/InForm Platform (2.9 MB) Bruce Homer, Pfizer
	Cellular Signaling and Activation State-Specific Antibodies (8.5 MB) Randy Wetzel, Cell Signaling Technology

Next Gen Sequencing & Genomics
	Molecular Testing for 595 Severe Childhood Recessive Diseases by Next-Generation Sequencing (1.9 MB) Darrell Dinwiddie, Children's Mercy Hospital, Kansas City
	Large Scale Analysis of Alternative Splicing and Other Applications Using LabChip Technology (4.6 MB) Roscoe Klink, University of Sherbrooke
	NimbleGen SeqCap EZ Automation: The Solution for High Throughput Genomics Research (988 KB) Marilou F. Wijdicks, Roche NimbleGen, Inc.
	Eliminating Sample Preparations Bottlenecks in High-Throughput Sequencing (568 KB) Joe Don Heath, NUGEN Corporation
	An Automated Solution for High-Throughput Second Generation Sequencing Library Preparation and Target Enrichment (1.5 MB) Christina Siebert, University of Miami
	Eliminating Sample Preparations Bottlenecks in High-Throughput Sequencing (916 KB) David LaHaie, NUGEN Corporation
	Automation of Multiple Applications in a Multi-Platform Environment (1.5 MB) Melanie Febrer, TGAC
	Automating Your Second Generation Sequencing Pipeline: What to Consider for Library Preparation and Sequence Capture (4.9 MB) Toumy Guettouche, University of Miami
	PCR Automation in a High Throughput Finishing Pipeline (2.8 MB) Lance Green, Los Alamos National Laboratory
	Sequencing Cancer Genomes; towards personalized cancer treatment (9.0 MB) Marco Koudijs, University Medical Center, Utrecht

Small Molecule Discovery & Development
	Predicting Safety Liabilities in Early Drug Development (1.8 MB) Karen Leach, Pfizer
	Doing More for Less: A Cost-Effective Solution for Biochemical & Biophysical Project Support (973 KB) Adam Shutes, EMD Serono Research Institute
	Template Directed Assembly for Receptor Tyrosine Kinases (1.3 MB) Edward Esposito, Ph.D., Senior Research Scientist, Blue Sky Biotech
	Development of a Small Molecule Inhibitors for Histone Methyltransferase G9a (2.3 MB) Victoria Korboukh, University of North Carolina
	Applying Microfluidic Technology to Epigenetic Probe Discovery (2.3 MB) William Janzen, University of North Carolina - Chapel Hill
	Mechanisms of Protein Kinase Activation: A Study Based on EZ Reader Data (3.6 MB) Richard Bayliss, University of Leicester
	Kinase Specificity Testing During SMW Lead Discovery and Optimization (2.9 MB) Joerg Trappe, Novartis Institutes for BioMedical Research
	Integrated Caliper Platforms for finding Small Molecule Interactors of Proteins (3.0 MB) Tine Skovgaard, Novo Nordisk

Proteins & Biologics
	Development and Validation of Microchip CE-SDS Methods for Antibody Purity Analysis (192 KB) Bruce Ricart, Eli Lilly and Company
	A Platform for Automated Small Scale Protein Purification (1.1 MB) Ruth Steele, Johnson and Johnson
	Practical Ways to Maximize Accuacy and Precision of LabChip Methods for Purity Analysis of Proteins (468 KB) Michael Smith, Glaxo Smith Kline
	Evaluation of High Throughput Capillary Electrophoresis for In-Process Virus Quantification (641 KB) Jurgen Wruss, Intercell
	Use of the Caliper GXII in High Throughput Downstram Process Research (641 KB) Katy Jinks, GSK
	Capilllary Electrophoresis: A Tool for the Production of Recombinant Viral Proteins (1.4 MB) Coutard Bruno, AFMB Lab
	Production of Vaccine Antigens and Carriers Using Expression Technology and HTP Microchip CGE Analysis (1.2 MB) Jeff Allen, Pfenex Inc.

Molecular Diagnostics
	DPO Technology-A Novel Oligo Platform for Super Multiplex PCR (1.4 MB) David Dolinger, VP Business Development, Seegene USA
	Use of the Caliper GX System in Ice COLD-PCR Mutation Detection Testing (454 KB) Katherine Richardson, Transgenomics
	Clinical Diagnostic Methods to Interpret LabChip GX Data (1.5 MB) David Olson, Access Genetics

Biomarker Discovery
	Applications of Multispectral Imaging in Surgical Pathology (3.3 MB) Mike Feldman, University of Pennsylvania
	Biomarker Discovery for Oncology (1.9 MB) Edward Stack, Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute

COG 2010 Presentations

Keynote Presentations
	Next Generation Tools Enabling a Revolution in Medicine (4.8 MB) Kevin Hrusovsky, Caliper Life Sciences
	The Future of Life Sciences: Fluidics & Imaging (2.5 MB) George Church, Harvard Medical School

Small Molecule Drug Discovery
	European COG
	Studies of Kinase Mechanism Using the Caliper Microfluidic Assay Patform (963 KB) Anthony Dossang, GSK Harlow, UK
	Application and Integration of LabChip Microfluidics in Screening (711 KB) Richard Cains, AstraZeneca, UK
	Introduction to Caliper Kinetic aAssays - Enhancing the Biology Decision Making of a Kinase Screening Programme (527 KB) Linda Kitching, Pfizer, Sandwich, UK
	Selectivity Between Aurora A and Aurora B: Insights From MLN8054 (1.3 MB) Charlotte Dodson, Institute of Cancer Research, London, UK

	USA COG
	Caliper Profiling Service in GNF Drug Discovery (183 KB) Yong Jia, Genomics Institute of Novartis Research Foundation
	Pharmacological Inhibition of a Kinase involved in Insulin Signaling (247 KB) Siobhan Malaney, Formerly from Tanabe
	Cathepsin S Inhibitor Drug Development in a Virtual Company Model Using Caliper Discovery Alliances and Services (1.8 MB) Leslie Holsinger, Virobay
	Development, Validation and Implementation of an Assay for Identifying Inhibitors of Soluble Adenyl Cyclase Using the Caliper LC3000 (1.5 MB) Derek Hook, University of Minnesota
	Internal Kinase Selectivity Screening Made EZ (604 KB) Laurie Lebrun, Celgene Corporation
	The Use of Caliper LifeSciences Microfluidic Technology to Define a New Discovery Paradigm Adam Shutes, EMD Serono
	Metabolic Stability: 384 or 96, What's Your Throughput? Mark Snyder, Pfizer
	Promoting Illiteracy in Epigenetics: "Channeling" Chemical Probes for Methyl-Lysine Tim Wigle, University of North Carolina
	Supporting Kinase Discovery Progams Wtih the Caliper EZReader Bill Janzen, University of North Carolina
	Characterization of Slow Binding HDAC Inhibitors by Caliper Assay Yan-Ling Zhang, Broad Institute
	Application of Label-Free Assay Technology in Drug Discovery Services Scott Perschke, Caliper Discovery Alliances & Services
	The Value of Microfluidics as a Tool for Screening Jon Wingfield, Astra Zeneca

Biologics/Vaccines/Protein Science
	European COG
	High Throughput Pull-down Assays in Aptamer Identification (923 KB) David Bunka, University of Leeds
	Implementation of a Caliper LabChip GXII in OPPF-UK (1.9 MB) Louise Bird, OPPF-UK
	Protein Expression Screening (1.7 MB) Thomas Purkarthofer/Roland Weis, VTU Technology

	USA COG
	Analytical Capabilities of LabChip Technology (711 KB) Migani Damiano, Biogen Idec Pharmaceuticals
	LabChip GXII for High Throughput Analysis of Protein Quality Bahram Fathollahi, Caliper Life Sciences
	PhyNexus Separation and Purification with Caliper Robotics and LabChip Technologies Solutions for High Throughput Protein Analytics (2.8 MB) Christopher Suh, PhyNexus Inc.
	The Macrolab: Harnessing the Power of Automation to Solve Problems in Cloning and Protein Purification (2.4 MB) Abbey Hartland, MacroLab Core Facility, University of CA - Berkeley
	Fully Automated Sample Processing and HTP Microchip CGE Analysis for Rapid Identification of Microbial Production Strains Pfēnex Expression Technology (2.4 MB) Jeff Allen, Pfenex Inc.
	Implementation of LabChip Methods in Quality Control to Replace SDS-PAGE for Release and Stability Testing (702 KB) Stacey Traviglia, Biogen Idec
	High Throughput N-Linked Glycan Analysis in Support of Cell Line Screening (3.5 MB) Peter Bryngelson, Biogen Idec
	Novel Analytical Technology to Support Biologics Development: Caliper GX II Biologics Development: Caliper GX II System Application Evaluation (176 KB) Mei Lin, Bristol-Myers Squibb
	Replacing SDS-PAGE: comparison of Caliper LC GXII to other CE platforms (763 KB) Michael Smith, GSK

Genomics/Molecular Diagnostics
	European COG
	Eliminating Manual Steps in a High-Throughput Genotyping Workflow (1.2 MB) Heiko Cziudaj, Taconic/Artemis
	High Throughput Primer Validation for Next Generation Sequencing (3.3 MB) Bram de Wilde, University of Ghent
	Sciclone's Use for Complete Sequencing Automation (170 KB) Jean-Francois Vanbellinghen, University of Liege
	Laboratory Automation in Academia (4.9 MB) David Egan, UMC Utrecht

	USA COG
	New Applications in Genomics (3.7 MB) Isaac Meek, Caliper Life Sciences
	Genome, Epigenome, and Transcriptome Study by Deep-Sequencing using Next Generation Sequencing Technology (4.5 MB) Ryan Kim, National Center for Genomic Resources
	High Throughput PCR process for Finishing Genomes (1.7 MB) Beverly Parsons, Los Alamos National Labs - Joint Genome Institute
	High-Throughput Nucleic Acid Purification solutions on Zephyr Genomics Workstation (3.9 MB) Mimi Ly, Machery Nagel (Bjoern Henze)
	Microfluidic Protein Analysis at the Seattle Structural Genomics Center for Infectious Disease (2.9 MB) Amy Raymond, Emerald Biostructures
	Caliper LabChip GX Development and Implementation (1.0 MB) Dave Olsen, Access Genetics
	DNA Polyermase Development via Microfluidics and Database-Integrated Analysis (1.0 MB) Nicole Nichols, New England BioLabs Inc.
	Integration of the Caliper GX as a Quality Checkpoint for High Throughput Next Generation Sequencing Sample Preparation (1.4 MB) Andrew Barry, Broad Institute
	Nextera™ NGS Library Preparation: From Nanograms of DNA to Sequencer-Ready Libraries in Under Two Hours (2.0 MB) Nick Caruccio, Epicentre Biotechnologies
	Coupling the Transgenomic SURVEYOR® Scan K-RAS Mutation Detection Kit and COLD-PCR technology with the Caliper LabChip® GX System (1.1 MB) Ben Legendre, Transgenomic
	Annotation and Phenotypic Analysis of Cancer-Associated Alternative Splicing (3 MB) Roscoe Klick, University of Sherbrooke

Preclinical Imaging Applications & Technologies
	USA COG
	Optical Imaging of Cerenkov Light Generation From Positron-Emitting Radiotracers Matthew Silva, Millennium, The Takeda Oncology Company
	Applications for Optical Imaging using Positron-Emitting Radiotracers Robbie Robertson, Millennium, The Takeda Oncology Company
	IVIS and Humanized Mouse Models: Applications for Stem Cells, Viruses, Malaria Jennifer Moffat, SUNY Upstate Medical University

COG 2009 Presentations

	Chemical Genomic Approaches to Discovery Utilizing Caliper LabChip Technology William Janzen, University of North Carolina at Chapel Hill
	Automation in Drug Development: Challenges and Rewards Drané O’Brien, Boehringer Ingelheim Pharmaceuticals, Inc.
	Strategy, Struggles, and Success of Strategy, Struggles, and Success of Monitoring Process Related Impurities Monitoring Process Related Impurities with Automation Karen Blank, Biopharmaceutical Analysis, Wyeth
	Biopharmaceutical Production Using Pfēnex Expression Technology™ and HTP Microchip-SDS-CGE Jeff Allen, Pfēnex, Inc.
	Identification of Unknown Target Antigens using Target Antigens using PhyNexus Technology Claudia Fieger & Tim Hotaling, Macrogenics
	Development of an Automated Kinase Screening Platform Using the LabChip EZ Reader II Adam Shutes, EMD Serono Research Institute

	High-Throughput Screening for Protein Engineering of Industrial Enzymes Jeffrey V. Miller, Genencor
	New Technologies for Enhanced Biopharmaceutical Analysis Nathan A. Lacher, Pfizer
	Assay Development and Inhibitor Characterization For Protein Kinases Using an LC 3000 Jeffery Hirsch, Pfizer
	Compounds That Target Host Cell Proteins Prevent Varicella-Zoster Virus Replication in Culture, Ex-Vivo, and in SCID-Hu Mice Jenny Rowe, SUNY Upstate Medical University
	Kinase Profiling Using a Mobility Shift Assay Platform and its Applications Masaki Gouda, Carna Biosciences
	Caliper Technology & Automated Kinase Screening at EMD Serono Adam Shutes, EMD Serono
	Caliper LabChip Technology in the Paralell Development of Small Molecule Inhibitors of Tyro3, Axl, and Mer (TAM) Kinases Amy Van Deusen, University of North Carolina at Chapel Hill
	Selectivity Profiling and Mechanistic Characterization of Phosphodiesterase Inhibitors using a Microfluidic Assay Edmond Massuda, Caliper Discovery Alliances & Services (CDAS)
	Genetic Screens in Human Tumor Cells Edward Richards, Harvard Medical School
	Analytical Capabilities of LabChip Technology Sharmila Babu, Biogen ICEC
	Coupled Assays for Analysing Enzymatic Activities of Proteins Involved in the cAMP Signaling Pathway Kornelia Hampel, Biaffin GmbH & CO KG
	Using LabChip 3000 for Phosphatase Screening Carola Seyffarth & Andreas Oder, Screening Unit AG Kries, FMP

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Caliper Owners Group (COG)