Optical  Imaging

Optical imaging is a technology that measures light produced by biological or chemical moieties. At Caliper Life Sciences (formerly Xenogen), we’ve always viewed it as ‘window of opportunity’ for the non-invasive spatiotemporal visualization of biological phenomena inside a live animal. Optical imaging technologies rely on light producing optical reporters such as luciferase and fluorescent proteins, fluorescent dyes and conjugates. Genes encoding luciferase and fluorescent proteins can be engineered into cells (e.g., cancer cell lines and infectious disease agents) and animals (transgenic mice and rats) to enable them to produce light that can then be visualized through the tissues of a live animal using specialized imaging equipment and software designed and built by the company. These highly sensitive dual bioluminescence and fluorescence imaging systems allows significantly fewer animals to be used due to the generation of superior data and better biostatistics.

With over2600 publications in the scientific literature, our novel patented imaging technology has been widely embraced by researchers worldwide because of its industry-leading sensitivity, physiological relevance, multi-functionality, high-throughput and user-friendly detection capabilities. To date, Caliper’s technology has been used predominantly to facilitate research in areas such as oncology, infectious disease, inflammation, neurobiology, stem cell and transplantation research, cardiovascular disease and toxicology.